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From Memphis, Tennessee (Approx: 150 miles):
From Memphis, travel East on I-40 to I-240. Travel South on I-240 to U.S. Highway 72. Travel East on U.S. Highway 72 for approximately 135 miles. This will come into U.S. Highway's 72 & 43 in Muscle Shoals/Tuscumbia. Follow Hwy 43 (Woodward Avenue) into Florence.
From Nashville, Tennessee (Approx: 135 miles):
From Nashville, travel Southwest on I-40 to I-65. Take I-65 South to U.S. Highway 72 (Athens, AL). Travel West on U.S. Highway 72 for approximately 45 miles. This will bring you into Florence.
From Chattanooga, Tennessee (Approx: 175 miles):
From Chattanooga, travel West on I-24 to U.S. Highway 72. Take Highway 72 West for approximately 110 miles. This will bring you into Florence.
From Atlanta, Georgia (Approx: 260 miles):
From Atlanta, travel West on I-20 to Birmingham. In Birmingham, take I-20 to I-65. Take I-65 North to Alabama Highway 157 (University of North Alabama Highway). Take Highway 157 Northwest for approximately 60 miles. This will bring you into U.S. Highway's 72 & 43 in Muscle Shoals/Tuscumbia. Follow Hwy 43 (Woodward Avenue) into Florence.
Alternate Route from Atlanta:
From Atlanta, travel West on I-20 to Birmingham. In Birmingham, take I-20 to I-65. Take I-65 North to U.S. Highway 72 (Athens, AL). Travel West on U.S. Highway 72 for approximately 45 miles. This will bring you into Florence.
From Birmingham, Alabama (Approx: 120 miles):
Take I-65 North to Alabama Highway 157 (University of North Alabama Highway). Take Highway 157 Northwest for approximately 60 miles. This will bring you into U.S. Highway's 72 & 43 in Muscle Shoals/Tuscumbia. Follow Hwy 43 (Woodward Avenue) into Florence.
Alternate Route from Birmingham:
Take I-65 North to U.S. Highway 72 (Athens, AL). Travel West on U.S. Highway 72 for approximately 45 miles. This will bring you into Florence.
From Huntsville, AL (Approximately 65 miles):
Travel West on U.S. Highway 72 for approximately 65 miles. This will bring you into Florence.